Cyclohexanepropanoic acid → 4-Cyclohexyl-1-cyclopentylbutan-1-one

HRID 1453267Notes

Reaction equation

HRID 1453267 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:13]1([CH2:19][CH2:20][C:21](O)=O)[CH2:18]CCCC1>>[CH:1]1([CH2:7][CH2:8][CH2:9][C:10]([CH:18]2[CH2:13][CH2:19][CH2:20][CH2:21]2)=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 69702Cyclohexanepropanoic acidHCID 75200Cyclohexanebutanoic acid

Product 1

HCID 219385244-Cyclohexyl-1-cyclopentylbutan-1-one

Procedure

The title compound was prepared analogously to Example A(44), where cyclohexanebutyric acid was substituted in place of 3-cyclohexylpropionic acid in Step 1 of that example. 1H NMR (DMSO-d6): δ 0.79-0.91 (m, 2H), 1.11-1.27 (m, 7H), 1.55-1.85 (m, 14H), 2.41 (t, J=7.4, 2H), 2.81-2.91 (m, 1H).

Sources & evidence

ORD record
ord-66986e7934704c9393728cefb1714d08
Source dataset
uspto-grants-2009_01
Patent number
US07473790B2

Reaction notes

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