3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one → HCID 58762495, compound

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Reaction Steps

The title compound was prepared analogously to Example C(4), where 3-Chloro-6-(3-cyclohexyl-propyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one (described in Step 2 of example C(30) was substituted in place of 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one and 5-Chloro-1-isopropyl-2-mercapto benzimidazole was substituted in place of 5-Pyridin-4-yl-4H-[1,2,4]triazole-3-thiol of that example. 1H NMR (DMSO-d6): δ 0.63-1.39 (m, 23H), 1.38 (d, J=6.9, 6H), 1.70-1.73 (m, 2H), 2.14-2.20 (m, 1H), 2.39 (d, J=17.0, 1H), 2.71 (d, J=17.0, 1H), 4.58-4.67 (m, 1H), 6.96 (dd, J=8.6, 2.1, 1H), 7.17 (d, J=2.1, 1H), 7.49 (d, J=8.6, 1H) 12.9 (brs, 1H); Anal. Calcd. For C29H39ClN2O3S.0.5H2O: C, 64.48; H, 7.46; N, 5.19; Found: C, 64.69; H, 7.30; N, 5.15. ESIMS (MH+): 532.

Provenance & Evidence