3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one → HCID 178519118, compound

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Reaction Steps

The title compound was prepared analogously to Example C(4), where 3-Chloro-6-(4-cyclohexyl-butyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one (described in Step 2 of example C(32) was substituted in place of 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one and 5-Chloro-1-isopropyl-2-mercapto benzimidazole was substituted in place of 5-Pyridin-4-yl-4H-[1,2,4]triazole-3-thiol of that example. 1H NMR (DMSO-d6): δ 0.73-1.36 (m, 23H), 1.43 (d, J=7.4, 6H), 1.49-1.55 (m, 2H), 1.84-1.88 (m, 2H), 2.18-2.23 (m 1H), 2.41 (d, J=17.0, 1H), 2.77 (d, J=17.0, 1H), 4.65-4.74 (m, 1H), 7.02 (dd, J=8.6, 1.9, 1H), 7.22 (d, J=1.9, 1H), 7.54 (d, J=8.6, 1H), 12.9 (brs, 1H); Anal. Calcd. For C30H41ClN2O3S.1.25H2O: C, 63.47; H, 7.72; N, 4.93; Found: C, 63.27; H, 7.44; N, 4.80. ESIMS (MH+): 546.

Provenance & Evidence