Phthalic Anhydride → 2-(1-Hydroxypentan-2-yl)isoindoline-1,3-dione

HRID 1453451Notes

Reaction equation

[C:1]1(=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])O1.[NH2:12][CH:13]([CH2:16][CH2:17][CH3:18])[CH2:14][OH:15]>>[OH:15][CH2:14][CH:13]([N:12]1[C:3](=[O:10])[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1]1=[O:11])[CH2:16][CH2:17][CH3:18]

Participants

Reactant 2

HCID 6811Phthalic Anhydride

HCID 2490172-Amino-1-pentanol

Product 1

HCID 667725062-(1-Hydroxypentan-2-yl)isoindoline-1,3-dioneYield 62%

Procedure

2-(1-hydroxypentan-2-yl)isoindoline-1,3-dione was prepared in a similar manner to example 9c using isobenzofuran-1,3-dione and 2-aminopentan-1-ol. Yield 62%.

Sources & evidence

ORD record: ord-da9ce0894a65498fa50b6577cb070ceb
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07476399B2

Reaction notes

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