1,3-Dibromopropane → HCID 68624457, compound

Participants

Reaction Steps

A solution of (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)-4,4-difluoropyrrolidine 2-carboxaldehyde diethylthioacetal IV (1 mmol), 1,3-dibromopropane (0.5 mmol) and K2CO3 (3 mmol) in dry acetone (40 ml) was refluxed for 48 h. After the completion of reaction as indicated by TLC, EtOAc-hexane (6:4), the reaction mixture was poured on to the water and then extracted with ethyl acetate. Evaporation of the organic layer gave the crude product, which was further purified by column chromatography on silica gel eluting with EtOAc-hexane (1:1) to give the pure 1,1′-{[(Propane-1,3diyl)dioxy]bis[2-nitro-5-methoxy-1,4-phenylene)carbonyl]}bis[4,4-difluoropyrrolidine-2-carboxaldehyde diethylthioacetal] V.

Provenance & Evidence