Trimethyl orthoformate → HCID 68820429, compound

HRID 1453533Notes

Reaction equation

HRID 1453533 reaction equation
[NH2:1][C:2]1[C:3]([S:9]([NH2:12])(=[O:11])=[O:10])=[C:4]([Cl:8])[S:5][C:6]=1[Cl:7].[CH:13](OC)(OC)OC>>[Cl:7][C:6]1[S:5][C:4]([Cl:8])=[C:3]2[S:9](=[O:10])(=[O:11])[N:12]=[CH:13][NH:1][C:2]=12

Participants

3

Reactant 2

HCID 9005Trimethyl orthoformateHCID 68824635HCID 68824635, compound

Product 1

HCID 68820429HCID 68820429, compound

Procedure

250 mg of the compound of Step C above are dissolved in 2.5 ml of trimethyl orthoformate. The solution is brought to boiling in an open vessel. After 1.5 hours, the reaction is complete. The solution is allowed to cool, yielding a beige precipitate which is collected by filtration, washed with diethyl ether and dried.

Workup

  1. customto boiling in an open vessel
  2. temperatureto cool
  3. customyielding a beige precipitate which
  4. filtrationis collected by filtration
  5. washwashed with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-332a5ca2ba434d6295e1f38768312efa
Source dataset
uspto-grants-2009_01
Patent number
US07476668B2

Reaction notes

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