Sodium borohydride → HCID 68825407, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of the compound of Step A above are dissolved in 5 ml of isopropanol. The solution is heated at about 60° C., and 400 mg of NaBH4 are added. After 20 minutes, the solvent is removed under reduced pressure and the residue is taken up in water. The pH is adjusted to about 5-6 and the product is extracted with 3×10 ml of chloroform. The organic phase is then dried over magnesium sulphate, filtered and then concentrated under reduced pressure. The residue is taken up in a minimum of chloroform and then the product is precipitated by addition of hexane. The product is then collected by filtration and washed with hexane and dried.

Provenance & Evidence