5,6-Dimethylbenzimidazole → HCID 178422320, compound

HRID 1453553Notes

Reaction equation

HRID 1453553 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[CH3:12][C:13]1[C:21]([CH3:22])=[CH:20][C:16]2[N:17]=[CH:18][NH:19][C:15]=2[CH:14]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:17]2[C:16]3[CH:20]=[C:21]([CH3:22])[C:13]([CH3:12])=[CH:14][C:15]=3[N:19]=[CH:18]2)[N:3]=1

Participants

4

Reactant 2

HCID 6755,6-DimethylbenzimidazoleHCID 53244122,6-Dichloropurine

Product 1

HCID 178422320HCID 178422320, compoundYield 43.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

283 mg of 2,6-dichloropurine, 5 ml of butanol and 219 mg of 5,6-dimethylbenzimidazole are mixed and brought to a temperature of 100° C. for approximately 17 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with isopropanol and drying under vacuum at 50° C. are carried out, and 194 mg of expected product are obtained, in the form of cream-colored crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with isopropanol
  4. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-f7681c7f79de41579a89f4a016fbd461
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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