Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | HCID 178478376 | HCID 178478376 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178448872 | HCID 178448872 | — |
Reaction Steps
200 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 0.6 ml (5 equivalents) of benzylamine, and the mixture is then heated at 120° C. for approximately 60 hours. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. Evaporation is carried out and a paste is formed in methylene chloride. Partial drying and drying under vacuum at 50° C. are carried out. 105 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07476670B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-060d2ec477874d7895090489dfe9fffe |
|---|
| Source note | uspto-grants-2009_01 |
|---|
