HCID 178478369, compound → HCID 178478725, compound

Participants

Reaction Conditions

Reaction Steps

1.31 g of trans-1,4-diaminocyclohexane are brought to its melting temperature (70° C.), 310 mg of product obtained in stage 1 above are added, and the mixture is then heated at 140° C. for approximately 18 hours. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with an MeOH—NH4OH: 98-2 mixture for eluent. 4 ml of ethanol and then 2 ml of hydrochloric acid-ethanol (8N) are added. Partial drying followed by washing with ethanol are carried out. Drying is carried out under vacuum. 23 mg of expected product are obtained, in the form of beige-colored crystals.

Provenance & Evidence