Aniline → 6-(1H-benzimidazol-1-yl)-N-phenyl-9H-purin-2-amine

HRID 1453575Notes

Reaction equation

HRID 1453575 reaction equation
[N:1]1([C:10]2[N:18]=[C:17](Cl)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)Cl>[N:1]1([C:10]2[N:18]=[C:17]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 6115AnilineHCID 178478376HCID 178478376, compound

Product 1

HCID 1784204846-(1H-benzimidazol-1-yl)-N-phenyl-9H-purin-2-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
140 °C

Procedure

300 mg of product obtained in stage 1 above are mixed with 0.52 ml of aniline and the mixture is then heated at 140° C. for approximately 72 hours. The mixture is allowed to return to ambient temperature for 48 hours. A paste is formed in methylene chloride and partial drying is carried out. 48 mg of expected product are obtained.

Workup

  1. custompartial drying

Sources & evidence

ORD record
ord-7336172d9d8a444fac05e4869e672623
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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