1,2-Diaminocyclohexane, cis- → HCID 178478708, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 0.5 ml (5 equivalents) of cis-1,2-diaminocyclohexane, and the mixture is then heated at 120° C. for approximately 3 days. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 85-15-1.5 mixture for eluent. 3 ml of ethanol and 3 ml of HCl-EtOH (hydrochloric acid-ethanol) are added. 34.3 mg of expected product are obtained.

Provenance & Evidence