Benzimidazole → HCID 178478376, compound

HRID 1453585Notes

Reaction equation

HRID 1453585 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[N:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[NH:14][CH:13]=1>C(O)CCC>[N:12]1([C:4]2[N:3]=[C:2]([Cl:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

Participants

4

Reactant 2

HCID 5798BenzimidazoleHCID 53244122,6-Dichloropurine

Product 1

HCID 178478376HCID 178478376, compoundYield 26.2%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

8 g of 2,6-dichloropurine, 150 ml of butanol and 5.5 g of benzimidazole are mixed and brought to a temperature of 80° C. for approximately 17 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum are carried out, and 3 g of expected product are obtained.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum

Sources & evidence

ORD record
ord-27bda66c492047fba311a3999830871d
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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