HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1453592Generated: October 30, 2026
4-Aminomethyltetrahydropyran → 6-(1H-benzimidazol-1-yl)-N-[(tetrahydro-2H-pyran-4-yl)methyl]-9H-purin-2-amine
https://huagongshe.com/reaction/1453592
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | HCID 178478376 | HCID 178478376 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-(1H-benzimidazol-1-yl)-N-[(tetrahydro-2H-pyran-4-yl)methyl]-9H-purin-2-amine | HCID 178419903 | — |
Reaction Steps
250 mg of product obtained in stage 1 above are mixed with 3 ml of DMSO and 531 mg μl of 4-aminomethyl-tetrahydropyran, and the mixture is then heated at 120° C. for approximately 2 days. The mixture is allowed to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. 142 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07476670B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-3175de9813ea4c21bcbd8d2a7a8a0431 |
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| Source note | uspto-grants-2009_01 |
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