dimethylindoline → HCID 178421929, compound

HRID 1453593Notes

Reaction equation

HRID 1453593 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[CH3:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]1C>C(O)CCC>[CH3:12][C:13]1[N:14]([C:4]2[N:3]=[C:2]([Cl:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)[C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2

Participants

4

Reactant 2

HCID 583485dimethylindolineHCID 53244122,6-Dichloropurine

Product 1

HCID 178421929HCID 178421929, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
100 °C

Procedure

The same procedure as in stage 1 of Example 1 is carried out, mixing 378 mg of 2,6-dichloropurine, 10 ml of butanol and 0.32 of dimethylindoline. The mixture is heated at 100° C. for approximately 5 hours and allowed to return to ambient temperature. Partial drying and washing with isopropanol are carried out. The product is dried and 423 mg of expected product are thus obtained.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with isopropanol
  4. customThe product is dried

Sources & evidence

ORD record
ord-856f77a6b4e24537b160385ede3c0657
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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