HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → HCID 178520995, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | L-Prolinol | HCID 640091 | — |
| Reactant | HCID 178478376 | HCID 178478376 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178520995 | HCID 178520995 | 64.6% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
250 mg of product obtained in stage 1 above are mixed with 2 ml of DMSO and 470 mg of (S)-(+)-2-pyrrolidinemethanol. The mixture is then heated at 110° C. for approximately 16 hours. The mixture is allowed to return to ambient temperature. A paste is formed in CH2Cl2 (methylene chloride). Drying is carried out under vacuum. 200 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07476670B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-c278d08b885a49e287bcf7850fccdf20 |
| Source note | uspto-grants-2009_01 |