Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Prolinol, (R)- | HCID 2724541 | — |
| Reactant | HCID 178478376 | HCID 178478376 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178520996 | HCID 178520996 | — |
Reaction Steps
250 mg of product obtained in stage 1 above are mixed with 2 ml of DMSO and 400 ml (4 equivalents) of (R)-(−)-2-pyrrolidinemethanol, and the mixture is then heated at 120° C. for approximately 5 hours. The mixture is allowed to return to ambient temperature. The DMSO is concentrated to dryness and the dry product is taken up in CH2Cl2, then partial drying is carried out. 258 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07476670B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-fd0897b92f0a43a6b5e8f31e825da520 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
