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HRID1453606

反应详情

EQUATION

反应方程式

HRID 1453606 的结构方程式

REACTANTS

反应物

2
结构：FC(F)(F)c1ccc2c(c1)N(c1nc(Cl)nc3[nH]cnc13)CC2
HCID178506067

未命名化合物

结构：N[C@H]1CC[C@H](N)CC1
HCID178511674

未命名化合物

PRODUCTS

生成物

1
结构：N[C@H]1CC[C@H](Nc2nc(N3CCc4ccc(C(F)(F)F)cc43)c3nc[nH]c3n2)CC1
HCID178511664

未命名化合物

收率 65.8%

CONDITIONS

反应条件

温度
140 °C

PROCEDURE

实验过程

340 mg of product obtained in stage 1 above are mixed with 800 mg of trans-1,4-diaminocyclohexane, and the mixture is then heated at 140° C. for approximately 8 hours. The mixture is allowed. to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 85-15-1.5 mixture for eluent. 275 mg of product are obtained and a paste is formed in HCl/ethanol: 50-50. Partial drying and drying under vacuum at 50° C. are carried out. 244 mg of expected product are obtained.

WORKUP

后处理

  1. customto return to ambient temperature
  2. customPurification