HCID 178506067, 화합물 → HCID 178511664, 화합물

HRID 1453606노트

반응식

HRID 1453606 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]([F:23])([F:22])[F:21])[CH:18]=3)[CH2:13][CH2:12]2)[N:3]=1.[NH2:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27][CH2:26]1>>[F:21][C:20]([F:23])([F:22])[C:17]1[CH:18]=[C:19]2[C:14]([CH2:13][CH2:12][N:11]2[C:4]2[N:3]=[C:2]([NH:24][C@H:25]3[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27][CH2:26]3)[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)=[CH:15][CH:16]=1

참가 물질

3

반응물 2

HCID 178506067HCID 178506067, 화합물HCID 178511674HCID 178511674, 화합물

생성물 1

HCID 178511664HCID 178511664, 화합물수율 65.8%

반응 조건

온도
140 °C

실험 절차

340 mg of product obtained in stage 1 above are mixed with 800 mg of trans-1,4-diaminocyclohexane, and the mixture is then heated at 140° C. for approximately 8 hours. The mixture is allowed. to return to ambient temperature. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 85-15-1.5 mixture for eluent. 275 mg of product are obtained and a paste is formed in HCl/ethanol: 50-50. Partial drying and drying under vacuum at 50° C. are carried out. 244 mg of expected product are obtained.

후처리

  1. customto return to ambient temperature
  2. customPurification

출처 및 근거

ORD 기록
ord-61bf00abd8c84bbca267cdb727b42bb3
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476670B2

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