6-Nitroindoline → HCID 86614108, compound

HRID 1453616Notes

Reaction equation

HRID 1453616 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[N+:12]([C:15]1[CH:23]=[C:22]2[C:18]([CH2:19][CH2:20][NH:21]2)=[CH:17][CH:16]=1)([O-:14])=[O:13]>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[N:21]2[C:22]3[C:18](=[CH:17][CH:16]=[C:15]([N+:12]([O-:14])=[O:13])[CH:23]=3)[CH2:19][CH2:20]2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 297576-NitroindolineHCID 53244122,6-Dichloropurine

Product 1

HCID 86614108HCID 86614108, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

378 mg of 2,6-dichloropurine, 7 ml of butanol and 328 mg of 6-nitroindoline are mixed and brought to a temperature of 90° C. for approximately 3 days. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum at 50° C. are carried out, and 573 mg of expected product are obtained, in the form of beige crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-6933398b18ff49e98b934a0a404154b2
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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