Isopropylamine → HCID 10410596, compound

HRID 1453620Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:31]=[CH:30][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][NH:26][CH2:27][CH2:28]C)=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH:32](N)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([CH2:25][NH:26][CH:27]([CH3:28])[CH3:32])=[CH:23][CH:24]=3)=[CH:30][CH:31]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 10094381HCID 10094381, compound

Product 1

HCID 10410596HCID 10410596, compound

Procedure

Compound 4 was synthesized using the procedure described for Compound 2 except that isopropylamine was used in the last reductive amination step. Compound 4 was obtained as a yellow gum. MS 433; 1H NMR (CDCl3) δ 4.10 (t, 2H), 3.86 (d, 2H, becomes singlet with D2O exchange), 2.80 (m, 1H), 1.09 (d, 6H).

Workup

customCompound 4 was synthesized

Sources & evidence

ORD record: ord-15c30ad617ec48d6b7ea143180e5be6c
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07476672B2

Reaction notes

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