Thionyl Chloride → HCID 13330038, compound

HRID 1453657Notes

Reaction equation

HRID 1453657 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]([NH:5][C:6]([CH3:11])([CH3:10])[C:7](O)=[O:8])=[O:4].S(Cl)([Cl:16])=O>>[F:1][C:2]([F:13])([F:12])[C:3]([NH:5][C:6]([CH3:11])([CH3:10])[C:7]([Cl:16])=[O:8])=[O:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 3035942-Methyl-2-(trifluoroacetamido)propanoic acid

Product 1

HCID 13330038HCID 13330038, compound

Procedure

0.54 g (2.71 mmol) 2-trifluoroacetylamino-isobutyric acid are combined with 1.8 ml (2.47 g, 20.8 mmol) thionyl chloride and refluxed for 2 hours with stirring. The mixture is then evaporated down i. vac. and any remaining thionyl chloride is eliminating by blowing dry nitrogen over it. The residue is taken up in diethyl ether and petroleum ether and evaporated down again by blowing dry nitrogen over it.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe mixture is then evaporated down i
  3. custompetroleum ether and evaporated down again

Sources & evidence

ORD record
ord-cd764f8397504778a8183c1ed5e2f6a4
Source dataset
uspto-grants-2009_01
Patent number
US07476663B2

Reaction notes

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