HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-[4-(methylthio)thieno[2,3-d]pyrimidin-6-ylmethylidene]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 4-(Methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde | HCID 17965859 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(methylthio)thieno[2,3-d]pyrimidin-6-ylmethylidene]methanamine | HCID 69059019 | 100% |
Reaction Steps
4-(Methylthio)thieno[2,3-d]pyrimidine-6-carbaldehyde (13 g), methylamine (33% in EtOH, 20.6 mL) and anhydrous MgSO4 (20 g) was stirred in DCM (465 ml) for 2 days at ambient temperature under an inert atmosphere. The reaction mixture was filtered then concentrated in vacuo to afford the title compound as a brown solid (13.8 g, 100%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07476677B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-ad9a625df2254fcf978fa0bdf9035fe2 |
| Source note | uspto-grants-2009_01 |