Sodium borohydride → HCID 67316103, compound

Participants

Reaction Steps

A solution of the product from example 1, step c (100 mg, 0.25 mmol) was dissolved in 4 mL MeOH. NaBH4 (30 mg, 0.75 mmol) was added and the reaction was stirred at rt for ½ h. Additional NaBH4 was added as needed in order to push the reaction to completion. The reaction was carefully quenched with HOAc until the evolution of hydrogen ceased. The resulting solution was partitioned between dichloromethane (DCM) and H2O. The organic layer was dried over MgSO4 and concentrated to an orange oil that was used without further purification. MS: ESI (negative): 397 (M−H).

Provenance & Evidence