Indole → 3-(1H-Indol-3-yl)-2-methyl-2,3-dihydro-isoindol-1-one

Participants

Reaction Steps

The product from example 20, step a) (650 mg, 3.98 mmol) and indole (780 mg, 6.67 mmol) were heated (neat) to 180° C. for 30 minutes. The reaction was cooled to rt and the product was recrystallized from ethanol/water to give 452 mg of the sub-title compound as a tan solid.

Provenance & Evidence