1-Bromo-3-methylbutane → HCID 11719117, compound

HRID 1453697Notes

Reaction equation

HRID 1453697 reaction equation
[O:1]=[S:2]1(=[O:34])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:21][C:22]([OH:24])=[O:23])[C:13]=2[CH3:25])=[N:4][N:3]1[CH2:26][CH2:27][C:28]1[CH:33]=CC=C[CH:29]=1.BrCCC(C)C>>[CH3:25][C:13]1[N:14]([CH2:21][C:22]([OH:24])=[O:23])[C:15]2[C:20]([C:12]=1[C:5]1[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[S:2](=[O:1])(=[O:34])[N:3]([CH2:26][CH2:27][CH:28]([CH3:33])[CH3:29])[N:4]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2

Participants

3

Reactant 2

HCID 78911-Bromo-3-methylbutaneHCID 11619814HCID 11619814, compound

Product 1

HCID 11719117HCID 11719117, compound

Procedure

The title compound was prepared from the product of example 19, step a) and 1-bromo-3-methyl-butane using the procedure described in example 17, step d). 1H NMR (DMSO-d6) δ 8.09 (d, J=7.2 Hz, 1H), 7.90 (t, J=7.5 Hz, 1H), 7.81 (t, J=7.8 Hz, 1H), 7.44 (d, J=7.8 Hz, 1H), 7.38 (d, J=8.1 Hz, 1H), 7.19 (d, J=7.8 Hz, 1H), 7.09 (t, J=7.8 Hz, 1H), 4.52 (s, 2H), 3.89 (t, J=6.9 Hz, 2H), 1.90 (s, 3H), 1.74 (q, J=6.9 Hz, 2H), 1.64 (sept., J=6.7 Hz, 1H), 0.92 (d, J=6.3 Hz, 6H); MS: ESI (negative): 438 (M−H).

Sources & evidence

ORD record
ord-dae4e673e3b145afac99e4a6953a3097
Source dataset
uspto-grants-2009_01
Patent number
US07476667B2

Reaction notes

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