1-Chloro-3-iodopropane → HCID 9985955, compound

Participants

Reaction Steps

The desired compound was synthesized from N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl) N-piperidin-4-yl-acetamide 103NLS56 (189 mg, 0.47 mmol), 1-piperidine (61 μL, 0.61 mmol) and 1-chloro-3-iodopropane (61 μL, 0.57 mmol) using the same method as for synthesis of 130AF09-145. Purification of the product by silica gel column chromatography, eluting with 10% methanol in dichloromethane, afforded the title compound (75.6 mg, 31%).

Provenance & Evidence