Diisopropylethylamine → N-(4-Chloro-3-trifluoro methyl phenyl)-2-[4-(4-pyridinyloxy)phenyl amino]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide	HCID 2307729	—
Reactant	4-(Pyridin-4-yloxy)aniline	HCID 11564589	—
Solvent	Dimethylformamide	HCID 6228	—
Product	N-(4-Chloro-3-trifluoro methyl phenyl)-2-[4-(4-pyridinyloxy)phenyl amino]-acetamide	HCID 11742948	5%

Reaction Conditions

Temperature	100 °C

Reaction Steps

A solution of 146.1 mg (0.54 mmol) of compound 9 in dimethylformamide (DMF) is given to a solution of 100 mg (0.54 mmol) of compound 2 and 0.1 ml (0.59 mmol) N-Ethyl-diisopropylamine in DMF. The reaction mixture is heated to 100° C. for 6 h, then evaporated and the residue is purified by preparative HPLC to yield 10.7 mg (5%) colourless solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07476683B2
Source dataset	uspto-grants-2009_01
ORD ID	ord-ecb7bb25ad3c4f0993528ccbb154ecad
Source note	uspto-grants-2009_01