Pyridine → N-(3-tert-butylisoxazol-5-yl)-2-chloroacetamide

HRID 1453795노트

반응식

HRID 1453795 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]([C:10]1[CH:14]=[C:13]([NH2:15])[O:12][N:11]=1)([CH3:9])([CH3:8])[CH3:7].N1C=CC=CC=1>ClCCl>[C:6]([C:10]1[CH:14]=[C:13]([NH:15][C:3](=[O:4])[CH2:2][Cl:1])[O:12][N:11]=1)([CH3:9])([CH3:8])[CH3:7]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 20956943-Tert-butyl-1,2-oxazol-5-amine

생성물 1

HCID 4962364N-(3-tert-butylisoxazol-5-yl)-2-chloroacetamide수율 97.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

Chloroacetic acid chloride (0.25 ml; 3.14 mmol) is dropped slowly into a stirred solution of 3-t-Butyl-5-amino isoxazole (400 mg; 2.85 mmol) in pyridine (0.3 ml; 3.71 mmol) and dichloromethane (2 ml), cooled to 0° C. Stirring is continued for 2 h at room temperature. The reaction mixture is diluted with dichloromethane, washed twice with 1 N aqueous hydrochloric acid, twice with an aqueous solution of NaHCO3 and with water. The reaction mixture is then dried over Na2SO4, filtered and evaporated to yield 600 mg (97%) brownish solid of 11.

후처리

  1. washwashed twice with 1 N aqueous hydrochloric acid, twice with an aqueous solution of NaHCO3 and with water
  2. dry with materialThe reaction mixture is then dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-4217c6ab413d4f80aa6c1efdbe3760eb
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476683B2

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