反应详情

The title compound was prepared from dimethyl 4-benzyloxy-1H-pyrazole-3,5-dicarboxylate using a procedure similar to that described in Example 2, Step 2, except that chloroacetone was used in place of bromo(phenyl)acetonitrile, and the silica gel chromatography gradient elution was 0-60% EtOAc/hexanes. 1H NMR (400 MHz, d6-DMSO) δ 7.46-7.34 (m, 5h), 5.44 (s, 2H), 5.06 (s, 2H), 3.83 (s, 3H), 3.78 (s, 3H), 2.20 (s, 3H); ES MS (M+1)=347.

1. washthe silica gel chromatography gradient elution