Dimethylamine → HCID 68955529, compound

Participants

Reaction Steps

The title compound was prepared from 3-benzyloxy-5,7-dimethyl-2-methoxycarbonyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-7-carboxylic acid using a procedure similar to that described in Example 2, Step 5 except that 2N dimethylamine in THF was used in place of 4-fluorobenzylamine, and the reaction time totaled 4 days. 1H NMR (400 MHz, d6-DMSO) δ 7.47-7.45 (m, 2H), 7.38-7.32 (m, 3H), 5.23 (dd, J=10.8, 16.0 Hz, 2H), 4.16 (d, J=13.6 Hz, 1H), 3.81-3.76 (m, 4H), 3.00 (s, 3H), 2.72 (br s, 6H), 1.78 (s, 3H); ES MS (M+H)=401.

Provenance & Evidence