Diethyl Ether → HCID 86617821, compound

Participants

Reaction Steps

To a stirring biphasic mixture of 40% aqueous KOH (20 mL) and Et2O (10 mL) at 0° C. was slowly added N-methyl-N-nitroso-N′-nitroguanidine (492 mg, 3.34 mmol). The mixture was stirred for 15 minutes, and the Et2O layer was transferred to a solution of ethyl 3-benzyloxy-7-chlorocarbonyl-5-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (262 mg, 0.669 mmol) in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 30 minutes, and the solvent was removed in vacuo to afford the title product. ES MS (M+H)=398.

Provenance & Evidence