Hydrochloric Acid → 3-Benzyloxy-5-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid

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Reaction Steps

To a solution of methyl 3-benzyloxy-5-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (221 mg, 0.701 mmol) in MeOH (5 mL) was added 1N aqueous NaOH (2 mL, 2 mmol). The reaction was stirred for several hours at room temperature and treated with 1N aqueous HCl (2 mL, 2 mmol). The solvents were removed in vacuo to afford the title product. 1H NMR (400 MHz, CD3OD) δ 7.51-7.49 (m, 2H), 7.54-7.26 (m, 3H), 5.26 (s, 2H), 4.39-4.36 (t, 2H), 3.82-3.72 (t, 2H), 3.12 (s, 3H); ES MS (M+1)=302.

Provenance & Evidence