Benzenemethanamine, 3,4-dichloro- → HCID 54723976, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 3-hydroxy-5-[(2-morpholin-4-yl)-2-oxoethyl]-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (15 mg, 0.044 mmol) was dissolved in 3,4-dichlorobenzylamine (1.5 mL) and heated to 90° C. for 30 minutes. Purification by reverse phase chromatography on a C-18 column using a gradient elution of 95-5% H2O (0.1% TFA)/CH3CN (0.1% TFA) and collection and concentration of the appropriate fractions afforded the title product. 1H NMR (400 MHz, d6-DMSO) δ 8.89-8.86 (t, 1H), 7.55-7.51 (m, 2H), 7.27-7.25 (d, 1H), 4.40-4.38 (d, 2H), 4.33-4.29 (m, 4H), 3.84 (br s, 1H), 3.74-3.71 (t, 2H), 3.58-3.52 (m, 4H), 3.42-3.39 (m, 4H); ES MS (M+1)=482.

Provenance & Evidence