Sodium Hydroxide → HCID 86595489, compound

HRID 1453918Notes

Reaction equation

HRID 1453918 reaction equation
[OH-].[Na+].Cl.[CH2:4]([C@H:11]1[C:15]([NH2:16])=[N:14][CH2:13][C@H:12]1[CH2:17][CH2:18][CH3:19])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[CH2:4]([C@H:11]1[C:15]([NH2:16])=[N:14][CH2:13][C@H:12]1[CH2:17][CH2:18][CH3:19])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86595490HCID 86595490, compound

Product 1

HCID 86595489HCID 86595489, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A basic resin-DIAION SA10A (14.5 g) that had been treated with aqueous sodium hydroxide solution was thoroughly washed with water and ethanol. The resin was then added to a solution of dl-[(3S,4R)-4-benzyl-3-propyl-3,4-dihydro-2H-5-pyrroleamine hydrochloride (1.63 g, 7.5 mmol) in methanol (30 ml) and the mixture was stirred for 30 minutes. After filtering the resin, the solvent was distilled off under reduced pressure to yield dl-[(3S,4R)-4-benzyl-3-propyl-3,4-dihydro-2H-5-pyrroleamine (1.45 g).

Workup

  1. washwas thoroughly washed with water and ethanol
  2. filtrationAfter filtering the resin
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-ef8eb2ef47fc473682a3fb36104907b2
Source dataset
uspto-grants-2009_01
Patent number
US07476688B2

Reaction notes

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