Ammonia methanol → HCID 11666663, compound

HRID 1453928Notes

Reaction equation

HRID 1453928 reaction equation
C([O:3][C:4](=O)[CH2:5][S:6][CH2:7][C:8]1[C:16]2[C:15]3[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:14]=3[O:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)C.CO.[NH3:25]>>[Cl:21][C:19]1[CH:18]=[CH:17][C:15]2[C:16]3[C:8]([CH2:7][S:6][CH2:5][C:4]([NH2:25])=[O:3])=[CH:9][CH:10]=[CH:11][C:12]=3[O:13][C:14]=2[CH:20]=1

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 68456746HCID 68456746, compound

Product 1

HCID 11666663HCID 11666663, compound

Conditions

Temperature
45 °C

Procedure

A suspension of 2-(7-chlorodibenzofuran-1-ylmethylsulfanyl)acetic acid ethyl ester (Compound Ic; 3.77 g, 11.8 mmole) in 50 ml 7N methanol/ammonia was stirred at 45° C. for one hour, and then at RT for 2 days. The suspension was filtered, washed by methanol, dried in vacuum to give 2.56 g of white solid.

Workup

  1. waitat RT for 2 days
  2. filtrationThe suspension was filtered
  3. washwashed by methanol
  4. customdried in vacuum

Sources & evidence

ORD record
ord-c2face7ebdaf41f79fa674535c60062f
Source dataset
uspto-grants-2009_01
Patent number
US07476690B2

Reaction notes

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