HCID 10247482, compound → HCID 9998311, compound

Participants

Reaction Steps

3-Cyano-7-methoxy-4-(3,4,5-trimethoxy-phenyl)-4H-chromene (25 mg, 0.07 mmol) was dissolved into EtOAc (1 mL). The solution was purged with nitrogen, and a catalytic amount of Pd/C 10% was added. The reaction was put under H2 pressure at 60 psi for 5 h. The solution was flushed with nitrogen, filtered on a Celite pad, and the pad was washed with EtOAc (5 mL). The solution was concentrated. Purification with bond elute silica gel using 20% EtOAc/hexane yielded 24 mg (72%) as a white solid. 1H NMR (CDCl3): 6.83 (d, J=8.3 Hz, 1H), 6.51 (d, J=2.6 Hz, 1H), 6.48 (dd, J=2.5, 5.1 Hz, 1H), 6.45 (s, 2H), 4.38-4.33 (m, 3H), 3.86 (s, 3H), 3.80 (s, 9H), 3.40-3.37 (m, 1H).

Provenance & Evidence