Formic Acid → HCID 10361732, compound

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2-Amino-3-cyano-7-methoxy-4-(3,4,5-trimethoxyphenyl)-4H-chromene (260 mg, 0.7 mmol) was dissolved into approximately 5 mL of formic acid. The obtained white suspension was stirred approximately 1 h at room temperature until it solubilized. The solvent was evaporated. The residue was dissolved into ethyl acetate (20 mL), washed with sodium bicarbonate saturated solution (2×20 mL), brine (20 mL), dried over sodium sulfate and concentrated to give approximately 210 mg of a mixture of diastereoisomers. 1H NMR (CDCl3): 7.12 (d, J=8.2 Hz, 0.5H), 6.82-6.67 (m, 2.5H), 6.41 (s, 1H), 6.37 (s, 1H), 4.48-4.43 (m, 1H), 4.25-4.02 (m, 1H), 3.86-3.78 (4s, 12H)

Provenance & Evidence