3-(Dimethylamino)phenol → [4-(3-Bromo-4,5-dimethoxyphenyl)-2-morpholin-4-yl-chroman-7-yl]-dimethyl-amine

Participants

Reaction Steps

A mixture of the 3-(3-bromo-4,5-dimethoxy-phenyl)-propenal (200 mg; 0.74 mmol), 3-(dimethylamino)phenol (101 mg, 0.74 mmol) and morpholine (65 μl; 0.75 mmol) in dry methanol (5 ml) was refluxed for 2 h and stirred at room temperature for 16 h. The solvent was removed and the intermediate [4-(3-bromo-4,5-dimethoxy-phenyl)-2-morpholin-4-yl-chroman-7-yl]-dimethyl-amine was obtained (350 mg).

Provenance & Evidence