Water → HCID 57528966, compound

Participants

Reaction Steps

To a solution of ethyl [(1S)-5-(2-{2-[3-(dimethylamino)-4-methylphenyl]-5-methyl-1,3-oxazol-4-yl}ethoxy)-2,3-dihydro-1H-inden-1-yl]acetate (175.0 mg, 0.38 mmol) in ethanol (1 mL) and THF (1 mL) was added LiOH (159 mg) followed by addition of 1 mL water. The reaction mixture was then stirred at rt for 4 h. The reaction mixture was then acidified to pH 5-6 and the solvent was removed by reduced pressure. The residue was redissolved in methanol, filtered through a plug of C8-Silica plug before preparative HPLC purification using 10 to 70% acetonitrile in water to afford desired product 156 mg (95% yield). 1H NMR (300 MHz/CD2Cl2) δ 7.96 (s, 1H), 7.80 (d, 1H), 7.35 (d, 1H), 7.06 (d, 1H), 6.77 (s, 1H), 6.67 (d, 1H), 4.21 (t, 2H), 3.47 (qr, 1H), 3.11 (s, 6 H), 2.97 (t, 2H), 2.75-2.90 (m, 2H), 2.70 (dd, 1H), 2.54 (s, 3H), 2.29-2.46 (m, 5H), 1.65-1.78 (m, 1H). EI-LCMS(rel abundance), m/z 435.4 (MH+, 100%). HPLC RT: 3.52 min.

Provenance & Evidence