HCID 68833946, compound → HCID 68833938, compound

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Reaction Steps

A suspension of 1-benzyl 4-tert-butyl 2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)succinate (1.00 g, 2.12 mmol) and silica gel (10.6 g) in toluene (50 mL) was heated at reflux for 3 h. The crude mixture was cooled to room temperature and filtered. The filter cake was washed with dichloromethane/methanol (8:2; 2×100 mL) then the organic filtrates were combined and evaporated to dryness to give the title compound as a while solid (0.83 g, 94%). LC/MS: 4.03 min; z/e 432, calcd (M+18) 432. 1H NMR (400 MHz: DMSO-d6): 7.05 (7H), 6.60 (2H), 4.95 (2H), 3.85 (1H), 2.85 (1H), 2.40 (1H), 0.80 (9H), 0.00 (6H).

Provenance & Evidence