反应详情

温度

27.5 °C

To a mixture of 4-bromo-3,5-dimethoxybenzylalcohol (44.5 g), triethylammonium benzyl chloride (2.05 g) and 20% aqueous sodium hydroxide solution (288 g) was added diethyl sulfate (41.7 g) under ice-cooling, and the mixture was stirred overnight at 25-30° C. After stirring for 1 hour at 70° C., the mixture was cooled and extracted with toluene. The toluene layer was washed with water and saturated aqueous NaCl solution and dried over magnesium sulfate. The solvent was removed in vacuo to yield 4-bromo-3,5-dimethoxybenzyl ethyl ether (49.5 g) as colorless oil.

1. temperaturecooling
2. stirringAfter stirring for 1 hour at 70° C.
3. temperaturethe mixture was cooled
4. extractionextracted with toluene
5. washThe toluene layer was washed with water and saturated aqueous NaCl solution
6. dry with materialdried over magnesium sulfate
7. customThe solvent was removed in vacuo