反应详情

tert-Butyl 3-methoxybenzyl((2R,3S)-3-(3-acetyl-5-(benzamido)-benzamido)-4-(3,5-difluorophenyl)-2-hydroxybutyl)carbamate (15 mg, 0.021 mmol) was dissolved in MeOH (0.1 mL) and sodium borohydride (1.0 mg, 0.028 mmol) was added. The reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated and partitioned between ethyl acetate and H2O. The organic layer was separated and concentrated under vacuum to give the title compound (14 mg): HPLC retention time: 2.267 min (method A). MS (ESI) (M+H)+ 732.39.

1. concentrationThe mixture was concentrated
2. custompartitioned between ethyl acetate and H2O
3. customThe organic layer was separated
4. concentrationconcentrated under vacuum