HCID 68839721, compound → HCID 68844620, compound

HRID 1454220Notes

Reaction equation

HRID 1454220 reaction equation
CO[C:3]([C:5]1[N:6]=[C:7]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:8]2[C:13]([C:14]=1[O:15]C)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][CH3:33])=[C:28]([S:34]([CH3:37])(=[O:36])=[O:35])[CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][CH3:33])=[C:28]([S:34]([CH2:37][C:3]([C:5]2[N:6]=[C:7]([CH2:17][C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[C:8]3[C:13]([C:14]=2[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=3)=[O:4])(=[O:35])=[O:36])[CH:27]=1

Participants

3

Reactant 2

HCID 68839721HCID 68839721, compoundHCID 68841980HCID 68841980, compound

Product 1

HCID 68844620HCID 68844620, compound

Procedure

2-(5-Chloro-2-methylamino-benzenesulfonyl)-1-[1-(4-fluoro-benzyl)-4-hydroxy-isoquinolin-3-yl]-ethanone (36a) was prepared from 1-(4-fluoro-benzyl)-4-methoxy-isoquinoline-3-carboxylic acid methyl ester and (4-chloro-2-methanesulfonyl-phenyl)-methyl-amine as described in steps 1-4 of Example 8.

Sources & evidence

ORD record
ord-4e24a3e95a7648b2b3733d63643bda18
Source dataset
uspto-grants-2009_01
Patent number
US07479489B2

Reaction notes

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