2-Bromopropane → HCID 68876850, compound

Participants

Reaction Steps

To a solution of [2-(3,4-dichloro-phenoxy)-5-(3-oxo-piperazin-1-ylmethyl)-benzyl]-methyl-carbamic acid tert-butyl ester 79 mg, 0.16 mmol) in DMF (3.2 mL) at 0° C. was added NaH (90%, 7.6 mg). After 30 min, 2-bromopropane (15 μL, 0.16 mmol) was added and the reaction was allowed to come to rt and stir overnight. The mixture was quenched with satd. aq. NaHCO3 and extracted with DCM. The combined organic layers were dried (Na2SO4) and concentrated. The crude product was purified by FCC to provide the title compound (35 mg, 41%). MS (ESI): mass calcd. for C27H35Cl2N3O4, 535.20; m/z found, 536.2 [M+H].

Provenance & Evidence