Trifluoroacetic acid → HCID 57530054, compound

Participants

Reaction Steps

To a solution of {2-[4-dimethylaminomethyl-3-(pyridin-3-yloxy)-benzoylamino]-ethyl}-methyl-carbamic acid tert-butylester (250 mg, 0.58 mmol) in CH2Cl2 (3 mL) was added trifluoroacetic acid (1 mL). The reaction was allowed to stir at rt for 16 h and then concentrated under reduced pressure. The residue was dissolved in CH2Cl2 (50 mL), washed with 1 M NaOH (15 mL), dried (Na2SO4), and concentrated under reduced pressure. FCC purification (MeOH/CH2Cl2) provided the desired product (0.13 g, 68%) as a yellow oil. MS (ESI): m/z found, 329.2 [M+H]+.

Provenance & Evidence