Trifluoroacetic acid → HCID 69040338, compound

Participants

Reaction Steps

A solution of [(6S,7R)-2-(4-fluorobenzyl)-2-aza-spiro[5.5]undec-7-yl]-carbamic acid tert-butyl ester (6.3 g, 1.4 mmol) in dichloromethane (30 mL) was treated with trifluoroacetic acid (30 mL) and stirred at room temperature for 1 hour. The solvent was removed under vacuum to give a residue. The residue was treated with 1.0 N aqueous sodium hydroxide. The mixture was extracted with dichloromethane and the organic phase was washed with water and saturated aqueous sodium chloride. The solvent was removed under vacuum to give an oil (4.2 g). 1H NMR (300 MHz, CDCl3) δ7.30-7.24 (m, 2H), 7.01-6.94 (m, 2H), 3.37 (m, 2H), 2.62 (m, 1H), 2.44 (m, 1H), 2.24 (m, 2H), 2.09 (m, 1H), 1.81 (m, 1H), 1.65-1.24 (m, 13H). Mass spec (ES+) m+/z 277.2 (M+H+).

Provenance & Evidence