Diethyl Ether → HCID 57283505, compound

Participants

Reaction Steps

A stirred solution of 4-[5-(4-fluoro-phenyl)-oxazol-4-yl]-pyridine (1.5 g, Reference Example 6) in dry tetrahydrofuran (50 ml), under an inert atmosphere and at −10° C., was treated with a solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (12.5 ml, 1M). After 0.5 hour the mixture was treated with N-formylmorpholine (1.5 ml). This mixture was stirred at room temperature for 16 hours then treated with diethyl ether (50 ml) and then filtered. The solid was suspended in 10% aqueous ammonium chloride solution (50 ml) and the resulting yellow solid filtered to give the title compound. MS: 269 [MH+].

Provenance & Evidence