反应详情

To a suspension of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(diethoxymethyl)-3-furyl]-6-methoxy-3-quinolinecarbonitrile (2.60 g, 4.79 mmol) in 70 mL of tetrahydrofuran is added 27 mL of 2N hydrochloric acid. The mixture is stirred at room temperature for 1.5 hours then slowly added to 200 mL of saturated aqueous sodium bicarbonate. The mixture is stirred for 30 minutes and the solid is collected by filtration washing with water and ethyl acetate. The solid is heated with ethyl acetate and the suspension is filtered to provide 1.23 g of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(5-formyl-3-furyl)-6-methoxy-3-quinolinecarbonitrile.

1. stirringThe mixture is stirred for 30 minutes
2. filtrationthe solid is collected by filtration
3. washwashing with water and ethyl acetate
4. temperatureThe solid is heated with ethyl acetate
5. filtrationthe suspension is filtered