Acetyl chloride → 1-bromo-4-[(Z)-2-chloro-2-(4-ethylphenyl) vinyl] benzene

반응식

C(O)(C(F)(F)F)=O.C([Cl:11])(=O)C.[Br:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH3:29])=[CH:24][CH:23]=2)=O)=[CH:15][CH:14]=1>>[Br:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[C:20](\[Cl:11])/[C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH3:29])=[CH:24][CH:23]=2)=[CH:15][CH:14]=1

참가 물질

반응물 3

HCID 6367Acetyl chloride

HCID 6422Trifluoroacetic acid

HCID 431604402-(4-Bromophenyl)-1-(4-ethylphenyl)ethan-1-one

생성물 1

HCID 156063231-bromo-4-[(Z)-2-chloro-2-(4-ethylphenyl) vinyl] benzene수율 92%

실험 절차

In a 100 mL flask, TFA (24.7 mL; 322.8 mmol) and acetyl chloride (18.34 mL; 258.23 rnmol) were added in one portion into 2-(4-bromophenyl)-1-(4-ethylphenyl) ethanone (Vc) (9.787 g; 32.28 mmol) at RT. Protocol and work-up was then similar with -those-described above. The title compoumd (m=9.60 g) was obtained in a 92% yield. Melting point: 75° C.