HRID1454432

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

反应SMILES：CCc1ccc(/C(Cl)=C/c2ccc(Br)cc2)cc1

HCID15606323

未命名化合物

PRODUCTS

产物

HCID57530618

1-Bromo-4-[(4-ethylphenyl)ethynyl]benzene

C16H13Br

收率 99.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To a 100 mL flask containing a solution of 1-bromo-4-[(Z)-2-chloro-2-(4-ethylphenyl) vinyl] benzene (VIc) (9.540 g; 29.66 mmol) in 1,4-dioxane (48 mL; 5 vols) and MeOH (14 mL; 1.5 vols), KOH (3.328 g; 59.32 mmol) was added in one portion. Protocol and work-up was then similar with those described above. Title compound (m=8.39 g) was obtained in a 99% yield. Melting point: 117° C.

WORKUP

后处理

additionwas added in one portion